Endocrine Abstracts

: Autoimmune polyglandular syndrome (APS) type 3 – is a rare orphan disease, which is a combination of autoimmune thyroid disease and diabetes mellitus (DM) type 1 and/or pernicious anemia, vitiligo, alopecia. Due to the rare occurrence in pediatric patients we give our own observation of early manifestation of APS type 3 A in a girl 10 years. Complaints in the primary treatment: sweating, irritability, cardiopalmus, weight loss. Survey results: ultrasound examination of ...

Pseudohypoaldosteronism is one of the least explored questions in clinical endocrinology. That leads to complexity in diagnosis and differential diagnostics of disease. A boy, aged 13 days was admitted to the hospital with complains: vomiting, low weight gain, constipation. Biochemical blood assay (BBA) and acid-base balance of blood: level of sodium −127 mmol/l (N 132 – 145 mmol/l), potassium −6.6 mmol/l (N 3.1 – 5.1 mmol/l), chlorine &...

Medical History of thirty five patients aged from one to sixteen years diagnosed with CAH have been analyzed in the Republican Center for Pediatric Endocrinology. Among the thirty five patients participating in the study (boys–fifty seven percent, girls –forty-three) seventy-one percent is with salt wasting form (SWF), twenty-two percent with virilising form (VF), three percent with non-classical form (NF). The mean weight SDS at birth is minus eight hund...

Objective: to assess the effects of associated autoimmune diseases on diabetes control, growth, lipid profile in children with type 1 diabetes mellitus (T1DM) and to determine the most predictive genetic, immune and metabolic risk factors of polyglandular autoimmunity in children with T1DM.Material and Methods: 89 children with combined autoimmune pathology (main group, age 11.82 ± 3.68 years) and 100 patients with isolated T1DM (control group, age ...

Aim: Evaluate the data of anamnesis, clinical-laboratory parameters, magnetic resonance imaging (MRI) findings, response to treatment in children with hyperprolactinemia (HProlact).Methods: We analyzed retrospectively 16 patients in the endocrinological department of University hospital (Minsk) with HProlact over 2004–2012 years. Boys (B) 6 (37.5%) (stage on Tanner 1 – 1 (17%); stage 2–3 – 3 (50%), stage 4 – 2 (33%), age at diagn...

Objective: Determination of changes in metabolic status and vitamin D, osteoprotegerin concentrations in obese children.Methods: We examined 212 children in the University Hospital from 2016 to 2018 yrs. Their anthropometric parameters (body mass index (BMI)) were determined. Blood levels of vitamin D, OPG, insulin were determined. In the biochemical blood test, the parameters of uric acid, glucose were evaluated. All children were divided into 2 groups:...

Objectives: To evaluate the efficacy of growth hormone (GH) treatment in children with Turner syndrome (TS) and to analyze the factors affecting the success of treatment.Methods: Retrospective observational study was conducted for 62 patients with TS. 3 groups of patients were identified: group 1 with karyotype 45, X (n=32), group 2 with mosaic variant 45,X/46,XX (n=8), group 3 with structural anomalies of X chromosome (n=22). ...

Aim: To assess changes of metabolic status in children with pituitary insufficiency.Methods: We examined retrospectively 28 children with pituitary insufficiency in the Endocrinological department of University hospital (Minsk) over 2001–2013 years. Group 1 (G1) - children with multiple acquired pituitary insufficiency (MAPI) after brain tumors treatment (11 children (73.3%) underwent surgical, 4 (26.7%) - combined treatment: surgical and radiation ...

Objective: To study feeding habits in children of different ages with alimentary obesity compared with normative values.Methods: We compared 3 days food diaries of 98 children with alimentary obesity observed in the Endocrinology Department of University Hospital (Minsk) with nutritional standards of healthy children recommended by Belarusian National Center for Hygiene, Epidemiology and Public Health – control (K). Patients were divided into three ...

Aim: To identify perinatal risk factors of the development of simple obesity in adolescence.Methods: We analysed retrospectively 327 histories of development in pubertal children, with the division into two groups: group 1 – 158 obese children (age 14.6±2 years, BMI 33.4±5 kg/m2), group 2 – 169 normal-weight patients (age 12.6±2.2 (P=0.2); BMI 20.5±1.2 kg/m2 (P<0.05)) from the Univ...